Michael Wheeler

Dr. Michael Wheeler PhD

Brigham and Women’s Hospital
Harvard Medical University
Boston (MA) | USA

My background is in immunology and neuroscience, with an emphasis on neuroimmune mechanisms controlling astrocytes and other glial cells in multiple sclerosis and CNS inflammation. As a post-doc, I made several contributions to our understanding of how astrocytes are influenced by, and exert influence over, inflammation of the central nervous system. In particular, I focused on: (1) the development of a new method, RABID-seq, used to analyze astrocyte networks with single-cell and genome-wide precision (Clark*, Gutiérrez-Vázquez*, Wheeler* et al., Science 2021); (2) a gut-immune-brain axis controlling astrocyte-induced apoptosis of pro-inflammatory effector T cells (Sanmarco*, Wheeler*, et al., Nature 2021); (3)astrocyte heterogeneity in multiple sclerosis and its animal model, EAE, which is regulated by pathogenic T cells and epigenetic modifications (Wheeler et al., Nature 2020); and (4) pathways exploited by environmental pollutants that exacerbate pro-inflammatory astrocyte responses in EAE and MS (Wheeler et al., Cell 2019). I also made several other contributions to our understanding of neuroimmune cross-talk in CNS inflammation focused on multiple sclerosis/EAE, glioblastoma, Zika virus infection, and epilepsy. My long-term goal is to apply our understanding of CNS immune responses in autoimmunity to other disorders, including neuropsychiatric and neurodegenerative diseases, with the objective of identifying therapeutically tractable molecular targets.

Israel Prize in Life Sciences to Prof. Michal Schwartz

stine - 22 March 2023

Prof Michal Schwartz of the Weizmannn Institute of Science, received the Israel Prize in Life Sciences for her pioneer work…

APSNI Courses

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APSNI 2023

stine - 13 March 2023

[memberonly]3rd APSNI Course | February 14th - 16th 2023 | Westmead (NSW), AustraliaDAY 1Session 1Reparative neuroinflammationV. Wee YongNovel techniques to…