Liblau, Roland

19 December 2021
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Head of the Neuroimmunology team at Infinity (Inserm U1291-CNRS UMR5051)
Toulouse | France

EDUCATION
1990: Medical Doctor degree and Medical Thesis, Paris
1991: Certification, Neurology Specialty Board
1995: PhD, in Immunology, Paris
1999: Accreditation to supervise Research programs
2001: Professor of Clinical Immunology, Toulouse

MEDICAL ACTIVITY
1983-1989: Residency program in Neurology, Paris
1994-2001: Head of the CSF analysis Laboratory, Salpêtrière Hospital, Paris
Since 2001: Professor of Clinical Immunology, Toulouse

RESERACH ACTIVITY
1986: Master in Immunology, Paris (Pr J-F. Bach)
1989-1991: PhD student, Pasteur Institute (Dr M.A. Bach)
1991-1994: Post-doctoral position with Pr H. McDevitt, Stanford University, USA
1996-2002: Head of the Neuro-Immunology Research Team, INSERM CJF97-11 then INSERM U546, Paris
Since 2003: Head of the Autoimmunity and Immunoregulation Research Team, INSERM U563, Toulouse
Since 2007: Chairman of the Department of Immunology and Infectious Diseases, INSERM U563
Since 2009: Deputy Director of the Pathophysiology Research Center of Toulouse Purpan (CPTP-INSERM U563)
2011-2020: Director of the Pathophysiology Research Center of Toulouse Purpan (CPTP-INSERM U1043-CNRS U5282)

Since 2021: Head of the Neuroimmunology team at Infinity (Inserm U1291-CNRS UMR5051)

CONSULTING AND REVIEWING
Medical and Scientific consultancy for:

– INSERM; AFSSAPS (French FDA); French Research Ministry; AERES; ANR MIME and MIE (member of the evaluating committee)

– French Multiple Sclerosis Society; French Myopathy Foundation (AFM)

– The Swiss Research foundation; Foundation for the support of MS research (Holland); DFG individual projects or SFB program projects (Germany); EU FP7 programs et IMI program; ERC Advanced grants (EU); Medical Research Council (UK); Welcome Trust (UK); WHO (Switzerland); Institute of Medicine (USA); Broad Medical Research Program (USA); European Medicine Agency, Canadian Institutes of Health Research (Canada).

– Prizes – Awards: Oudin prize ; Humboldt award ; Novo-Nordisk prize

– Companies

Reviewing of scientific articles:
New England Journal of Medicine; Nature; Science; Nature Medicine, Immunity; Science Translational Medicine; Nature Reviews Neurology; Nature Reviews Clinical Oncology Journal of Clinical Investigation; CELL Metabolism ; Journal of Experimental Medicine; PNAS USA; Lancet; Nature Communications; EMBO Journal; Trends in Immunology; CELL Reports ; Brain; Annals of Neurology; Acta Neuropathologica; Current Opinion in Immunology; Journal of Immunology; Neurology; PLoS genetics; American Journal of Pathology; European Journal of Immunology; Journal of Neuroimmunology; Neurobiology of Disease; GLIA;…

Editorial Board member:
Frontiers in Immune Tolerance since 2010, OncoImmunology since 2011, BRAIN Editorial Advisory Board 2015-2020, Journal of Molecular Medicine since 2019.

SCIENTIFIC SOCIETY RESPONSABILITIES

  • French Immunology Society (SFI) Board member (2009-2012)
  • President of the SFI from Jan 2010 to Dec 2012.
  • Scientific board member of the French MS society (ARSEP);
  • Head of the EFNS Panel on Neuroimmunology (2003-06);
  • Co-founder and member of the European School of Neuroimmunology (since 2000).
  • Member of the Teaching course committee for ECTRIMS and ACTRIMS/ECTRIMS congresses since 2009.
  • Since 2014, Member of the Executive Committee for ECTRIMS, the largest organization worldwide on research and treatment for multiple sclerosis.
  • Since 2016, Member of the International Advisory Board of the International Society of NeuroImmunology(ISNI)
  • Since 2017, member of the Henry Kunkel Society, New York, USA.Since 2016: Deputy Director of the Toulouse Excellence Center for Neurodegenerative Diseases (NeuroToul).

20 Selected Peer-reviewed Publications
1. R. Bernard-Valnet, D Frieser, X-H. Nguyen, L. Khajavi, C. Quériault, S. Arthaud,  S. Melzi, M. Fusade-Boyer, F. Masson, M. Zytnicki, A. Saoudi, Y. Dauvilliers,  C. Peyron, J. Bauer, RS. Liblau. Influenza vaccination induces autoimmunity against orexinergic neurons in a mouse model for narcolepsy. Brain in press

  1. H. Wiendl, C. Gross, J. Bauer, D. Merkler, A. Prat, and R. Liblau. Fundamental mechanistic insights learned from rare but paradigmatic neuro-immunological diseases. Nature Rev Neurol. 2021; 17(7):433-447.
  2. Gross CC, Meyer C, Bhatia U, Yshii L, Kleffner I, Bauer J, Tröscher AR, Schulte-Mecklenbeck A, Herich S, Schneider-Hohendorf T, Plate H, Kuhlmann T, Schwaninger M, Brück W, Pawlitzki M, Laplaud DA, Loussouarn D, Parratt J, Barnett M, Buckland ME, Hardy TA, Reddel SW, Ringelstein M, Dörr J, Wildemann B, Kraemer M, Lassmann H, Höftberger R, Beltrán E, Dornmair K, Schwab N, Klotz L, Meuth SG, Martin-Blondel G, Wiendl H, Liblau R. CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome. Nature Commun. 2019 Dec 18;10(1):5779.
  3. Walter O., Treiner E., Bonneville F., Mengelle C., Vergez F., Lerebours F., Delobel P., Liblau R., Martin-Blondel G. Treatment of Progressive Multifocal Leukoencephalopathy with Nivolumab. N. Engl. J. Med. 2019 Apr 25;380(17):1674-1676.
  4. Liblau RS. Put to sleep by immune cells. Nature2018; 562: 46-48 News & Views.
    6. Nguyen XH, Dauvilliers Y, Quériault C, Perals C, Romieu-Mourez R, Paulet PE, Bernard-Valnet R, Fazilleau N, Liblau R.  Circulating follicular helper T cells exhibit reduced ICOS expression and impaired function in narcolepsy type 1 patients.J. Autoimmun. 2018 Aug 6. pii: S0896-8411(18)30230-0.
    7. Yshii L, Hohlfeld R, Liblau R. Inflammatory diseases of the CNS caused by immune checkpoint inhibitors: status and perspectives.Nat Rev Neurol.2017Dec;13(12):755-763.
    8. C. Gebauer, B. Pignolet, L. Yshii,E. Mauré, J. Bauer, R. Liblau. CD4+ and CD8+ T cells are both needed to induce paraneoplastic neurological disease in a mouse model. Oncoimmunology. 2016 Dec 9;6(2):e1260212. doi: 10.1080/2162402X.2016.1260212. eCollection 2017.
    9. F.J. Hartmann, R. Bernard-Valnet, C. Quériault, D. Mrdjen, L.M. Weber, E. Galli, C. Krieg, M.D. Robinson, X-H. Nguyen, Y. Dauvilliers, R.S. Liblau*& B. Becher*. High-Dimensional Single-Cell Analysis Reveals The Immune Signature of Narcolepsy J. Exp. Med.Nov 14;213(12):2621-2633. *Shared last authorship.
    10. R. Bernard-Valnet, L. Yshii, C. Quériault, X-H. Nguyen, S. Arthaud, M. Rodrigues, A. Canivet, A-L. Morel, A. Matthys, J. Bauer, B. Pignolet, Y. Dauvilliers, C. Peyron, and R.S. Liblau. CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice. PNAS (USA).2016, 113(39):10956-61.
  5. L. Yshii, C. Gebauer, B. Pignolet, E. Mauré, C. Quériault, M. Pierau, H. Saito, N. Suzuki, M. Brunner-Weinzierl,J. Bauer, RS. Liblau. CTLA-4 blockade elicits paraneoplastic neurological disease in a mouse model. BRAIN.2016, 139(11): 2923-2934.
  6. Martin-Blondel G, Brassat D, Bauer J, Lassmann H, Liblau RS. CCR5 blockade for neuroinflammatory diseases. Nat Rev Neurol.2016 Feb;12(2):95-105.
    13. A. Ramadan, L. Lucca, N. Carrié, S. Desbois-Beaumel, P-P. Axisa, J Bauer, RS. Liblau* and LT. Mars* In situ expansion of polyspecific T cells that recognize distinct self-antigens sustains the progression of organ-specific autoimmunity. BRAIN. 2016. 139(5):1433-46. *Shared last authorship.
    14. Waisman A*, Liblau RS*, Becher B*. Innate and adaptive immune responses in the CNS. Lancet Neurol. 2015 Sep;14(9):945-55.
    15. Liblau RS, Vassalli A, Seifinejad A, Tafti M. Hypocretin (orexin) biology and the pathophysiology of narcolepsy with cataplexy. Lancet Neurol. 2015 Mar;14(3):318-28.
    16. Lucca LE, Desbois S, Ramadan A, Ben-Nun A, Eisenstein M, Carrié N, Guéry JC, Sette A, Nguyen P, Geiger TL, Mars LT, Liblau RS. Bispecificity for myelin and neuronal self-antigens is a common feature of CD4 T cells in C57BL/6 mice. J Immunol. 2014 Oct 1;193(7):3267-77
    17. Martin-Blondel G, Bauer J, Cuvinciuc V, Uro-Coste E, Debard A, Massip P, Delisle MB, Lassmann H, Marchou B, Mars LT, Liblau RS. In situ evidence of JC virus control by CD8+ T cells in PML-IRIS during HIV infection. Neurology.2013 Sep 10;81(11):964-70.
    18 Liblau RS, Gonzalez-Dunia D, Wiendl H, Zipp F. Neurons as targets for T cells in the nervous system. Trends Neurosci. 2013 Jun;36(6):315-24.
    19 Scheikl T, Pignolet B, Dalard C, Desbois S, Raison D, Yamazaki M, Saoudi A, Bauer J, Lassmann H, Hardin-Pouzet H, Liblau RSCutting edge: neuronal recognition by CD8 T cells elicits central diabetes insipidus. J Immunol. 2012 May 15;188(10):4731-5.
    20. Krishnamoorthy G, Saxena A, Mars LT, Domingues HS, Mentele R, Ben-Nun A, Lassmann H, Dornmair K, Kurschus FC, Liblau RS, Wekerle H. Myelin-specific T cells also recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis. Nat Med. 2009 15(6):626-32.

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