Sachiko Miyake

Professor, Department of Immunology,
Juntendo University Graduate School of Medicine
Tokyo | Japan

Sachiko Miyake, MD, PhD

Professor, Department of Immunology, Juntendo University Graduate School of Medicine

EDUCATION：

Tokyo Medical and Dental University, JAPAN         MD       1987     Medicine

Juntendo University, JAPAN         MD, PhD                       1994     Medicine

EMPLOYMENT:

Clinical fellow    Juntendo University, Tokyo, JAPAN                       1994-1995

Postdoctoral Fellow         Harvard Medical School, Boston, USA                    1995-1997

Instructor                       Harvard Medical School, Boston, USA                    1997-1999

Section Chief      National Institute of Neuroscience, Tokyo, Japan      1999-2013

Professor                       Department of Immunology, Juntendo University, Tokyo, Japan  2013-present

Research Interest:

Clinical Immunology, Rheumatology, Neuroimmunology

Selected Publication

1.The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha.Proc Natl Acad Sci USA 95(14):7927-7932, 19981.

2.A synthetic glycolipid prevents autoimmuneencephalomyelitis by inducing TH2 bias of natural killer T cells. Nature 413(6855): 531-534, 2001

3. Invariant Va19i T cells regulate autoimmune inflammation. Nat Immunol 7(9):987-994, 2006
4. Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica. Proc Natl Acad Sci USA 108(9):3701-3706, 2011
5. Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters. PLoS One 10(9):e0137429, 2015
6. Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3. Nat Commun 7:11639, 2016
7. Butyrate suppresses demyelination and enhances remyelination. J Neuroinflammation 16(1):165, 2019
8. Alterations of the gut ecological and functional microenvironment in different stages of multiple sclerosis. Proc Natl Acad Sci USA 117(36)22402-22412, 2020
9. Dysregulated B cell differentiation towards antibody-secreting cells in neuromyelitis optica spectrum disorder. J Neuroinflammation 19(1):6, 2022
10. a-synuclein orchestrates Th17 responses as antigen and adjuvant in Parkinson’s disease. J Neuroinflammation 22(1):38, 2025