- Regulatory B cells in a new model of multiple sclerosis
B cells contribute to multiple sclerosis (MS); depleting them improves clinical outcomes. However, current drugs deplete most B cells, including regulatory B cells (Bregs) with beneficial anti-inflammatory properties. Studying Bregs could lead to more specific and safer therapies. Recently, we found a population of Bregs in a new mouse model of MS. In this project, our goal is to determine the nature, anatomical distribution and function of these Bregs. This project will help not only to understand Bregs, but also to identify new biomarkers and therapeutic strategies for autoimmune diseases like MS.
- A novel dendritic cell-specific protein in demyelinating autoimmune diseases
Dendritic cells (DCs) orchestrate the activity of T cells, which play a central role in multiple sclerosis (MS. A major challenge in the field is to discover DC-specific molecules that would allow to identify and target DCs with accuracy and that would help to explain their unique properties. We have recently found a novel cell-surface protein of unknown function that is exclusively produced by DCs in a mouse model of MS. The goal of this project is to clarify the function of that protein, while exploiting it as a tool to better understand DCs and autoimmune demyelination. This project will provide fundamental, applicable and patentable knowledge about that protein as well as valuable tools for future studies.
We are looking for an enthusiastic, hard-working, highly motivated, rigorous, and interactive person with strong interest in neuroimmunology and the following qualifications:
- Degree (B.Sc., M.Sc., Ph.D.) in a relevant discipline
- Knowledge in immunology
- Good academic records
- Good writing skills
- Advantages: scientific publications and communications
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